2011-2013 Post-doctoral Fellowship, Department of Orthopaedic Surgery, University of Pennsylvania
My current and future research in tissue engineering will focus on the following topics:
– Automated cell culture systems (for applying controlled interventions and monitoring the resulting function)
– Control of expression of adult muscle phenotype (adult myosin isoforms: fast twitch & slow twitch)
– Compliant tendons (for mechanical impedance matching and the reduction of stress concentrations)
– Motor unit level control of engineered skeletal muscle constructs (a collaboration with CNCT in EECS)
– Nerve-muscle interface (to provide nerve-derived trophic factors and to aid in expression of adult phenotype)
– Angiogenesis and perfusion (to allow large tissue cross sections).
Dr. Dayton’s research involves developing new technologies for imaging blood flow, microvasculature, and molecular markers using ultrasound and microbubble contrast agents. Several of Dr. Dayton’s recent contributions to the field include techniques to improve the sensitivity and consistency of ultrasound imaging through optimization of contrast agent size distribution, the demonstration of high-resolution, high- SNR ultra broadband imaging, and techniques for real-time molecular imaging. An additional area of interest is ultrasound-mediated therapeutics with micro and nanoparticles. Dr. Dayton’s primary interest is in developing and applying tools for non-invasive assessment of angiogenesis progression and tumor response to therapy. Dr. Dayton’s lab is part of the UNC-NCSU Ultrasound Research Consortium
Dr. Daniele joined the faculty of North Carolina State University in August 2015. He is an Assistant Professor in the Department of Electrical & Computer Engineering, as well as the Joint Department of Biomedical Engineering. Dr. Daniele’s primary area of interest is the broad application of soft nanomaterials to engineer devices which monitor, mimic or augment biological function. Specific topics of research include wearable and implantable biosensors, organ-on-a-chip models, and human-machine interfaces.
2010-2013 Postdoctoral Fellowship Orthopedic Surgery, University of Michigan2007-2010 Postdoctoral Fellowship Chemistry, University of Michigan
Ke Cheng’s laboratory studies regenerative medicine by using patient-derived stem cells, biomaterials, micro-RNAs and bioengineering approaches. Translational research is a major focus of the lab. Prior to the launch of Cheng Lab at North Carolina, Dr. Cheng directed the stem cell lab for multiple human trials, including the world’s first clinical trial using cardiac stem cells to treat heart attach. Currently, we are testing the following strategies to treat cardiovascular diseases: 1) purified and more potent stem cell products derived from the natural mixture of cardiac stem cells; 2) biomaterials derived from patient’s own tissues; 3) micro-RNAs involved in tissue regeneration; 4) nano theranostic agents that can augment endogenous repair; 5) novel mechanisms of cell extravasation, namely angiopellosis.
Yevgeny joined the BME department in 2017. Research in his lab focuses on exploiting cutting-edge chemical, biomaterial and nanomedicine technologies to understand physiological responses during disease and regeneration and fulfill critical unmet needs in the clinic. His group will use chemical prodrug therapy, controlled drug delivery and nanomedicine to enable new forms of cancer chemotherapy and immunotherapy as well as treatment of infection and other diseases.
Dr. Brown joined the department in August 2015. Her research centers on developing novel microgel-based materials for a variety of biomedical applications including augmentation of hemostasis, enhanced wound healing, evaluation and modulation of cellular mechanotransduction and development of biosynthetic constructs for regenerative medicine. Current projects include development of microgel-based platelet-like particles (PLPs) and other microgel assemblies for augmentation of hemostasis and regenerative medicine. Additionally, she is exploring the use of microgel-based assemblies with finely controlled elastic and viscoelastic properties for investigating and controlling cellular mechanotransduction responses.