Magness Lab

The focus of research at Magness Lab is the genetic mechanisms that control intestinal and colonic stem cell maintenance and differentiation. The Lab uses the highly regenerative gut epithelium as a model system to understand how Sox-transcription factors control cell-fate decisions. The group has developed ‘gut-on-chip’ and high-throughput analysis platforms to assess the functional properties of single stem cells, multicellular organoids and biomimetic tissue constructs.