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The 5-year grant is funded through the National Institute of Health’s (NIH); National Institute on Aging (NIA).

Chondrocytes accumulate high levels of DNA damage with age and this may lead to a higher risk of developing osteoarthritis.

This research project seeks to understand how DNA damage leads to a particular type of cellular dysfunction known as senescence. The work will also explore whether activating more efficient DNA damage repair would be sufficient to slow the development of age-related osteoarthritis.

Dr. Diekman is an Assistant Professor in Biomedical Engineering, a department that spans UNC and NC State University.

UNC co-investigators for the project include Drs. Richard Loeser, Jeremy Purvis, Morika Williams and Becki Cleveland.

Grant number: R01AG081734


This article was originally published on September 21 by the UNC School of Medicine and can be read here. 

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