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Find Faculty / Scott Magness

Contact Information:

Scott Magness

111 Mason Farm Rd
MBRB Room 4337
Campus Box 7032
UNC Chapel Hill
(919) 966-6816

Research Areas:
  • Biomedical Microdevices
  • Regenerative Medicine
  • PhD, Genetics and Molecular Biology, University of North Carolina at Chapel Hill
  • BS, Chemistry/Biochemistry, University of California at San Diego


Dr. Magness’ research is focused on the basic biology of intestinal stem cells, the genes that control their behavior, and translational approaches to stem cell-based therapies for human disease and injury of the intestine. Furthermore, his research focuses on elucidating genetic mechanisms underlying stemness and developing translational models to establish a finer understanding of stem cell-driven regeneration dynamics in homeostasis and injury. Using a combination of genetic mouse models and micro-fabricated bioengineered platforms, Dr. Magness’ team is exploiting the self-renewal capacity and multi-potency of ISCs to develop long-term ex vivo models of the intestine and colon with primary tissues. These biomimetic models offer new solutions for compound screening and cell-based therapies.

Research Interests

Stem Cell Biology
Niche Dynamics
Tissue Engineering
Biomimetic Scaffolds
Single-Cell Biology
Stem cell maintenance and differentiation
Single cell analytics
High-throughput biomimetic culture platforms

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