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An interdisciplinary team spanning biomedical engineering, exercise and sports science, biostatistics and the Thurston Arthritis Research Center has received a new 5-year, $3M R01 Grant from the National Institutes of Health titled “Discovering the Mechanisms Linking Gait to Osteoarthritis Onset and Progression.”

The project is by co-principal investigators Jason Franz, associate professor in the Lampe Joint Department of Biomedical Engineering, and Brian Pietrosimone, professor in exercise and sport science. Additional collaborators include Brian Diekman and David Lalush, associate professors in the Lampe Joint Department of Biomedical Engineering, along with Todd Schwartz, professor and associate chair of biostatistics, and Lara Longobardi, associate professor of medicine.

The research team will investigate the underlying mechanistic pathway to explain how aberrant knee joint loading in walking alters the mechanical, biophysical and biological properties of tibiofemoral articular cartilage in individuals at risk for knee osteoarthritis. The researchers noted that “establishing this mechanistic pathway is the single most important milestone toward advancing precision gait retraining as an effective strategy for preventing knee osteoarthritis.”


For more information on NIH R01 Grants and their funding opportunities, please visit this page.

To learn more about the Applied Biomechanics Lab, lead by Jason Franz, please visit their lab website here.

For more information about Brian Pietrosimone’s Lab Group, please visit this page.

 

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